The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from <i>Vitex trifolia</i> L., to Trigger Apoptosis of Cervical Cancer Cells

<div>RTF-induced mitochondrial-dependent apoptosis in cervical cancer cells. (a) Effects of RTF on caspase and Bcl-2 family proteins; (b) effects of RTF on PI3K/Akt signaling proteins; (c) effects of RTF on MAPK signaling proteins. Cell were treated with RTF for 24 h, and the total proteins were extracted and subjected to western blot analysis using respective antibodies, and GAPDH was used as an internal control. (d) Immunofluorescence colocalization of Cyt c release. MitoTracker was used to locate the presence of cytochrome c. Cells without RTF treatment were used as control. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from <i>Vitex trifolia</i> L., to Trigger Apoptosis of Cervical Cancer Cells 

Figure 4 | The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells 