PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production

Figure 8

PGC-1α induces the gene expression of ROS-detoxifying enzymes and increase the activities of SOD, CAT, and GPX in the liver, which is associated with the activities of PPARα and PPARγ. (a) The activities of SOD, CAT, and GPX in the liver tissues from mice subjected to Ad-GFP, Ad-PGC-1α, Ad-shScramble, and Ad-shPGC-1α at 6 h after liver I/R (). (b) The relative gene expression of SOD1, SOD2, catalase, and GPX1 in the liver tissues from the mice were assessed by qRT-PCR (). (c) The activities of SOD, CAT, and GPX in the liver tissues from mice subjected to Ad-PGC-1α, Ad-PGC-1α+MK886, Ad-PGC-1α+GW9662, and Ad-PGC-1α+MK886+GW9662, relative to the Ad-GFP control at 6 h after liver I/R (). (d) The relative gene expression levels of SOD1, SOD2, catalase, and GPX1 in the liver tissues (). , , and .

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