Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway

Figure 1

100 μM H₂O₂ induces the degeneration of nucleus pulposus cells. When the concentration of H₂O₂ was more than 100 μm, (a) the proliferation rate of cells decreased significantly. The relative mRNA expression of (b) collagen II, (c) aggrecan, and (d) Sox-9 decreased significantly, while that of (e) collagen X and (f) MMP-3 increased significantly. (g, h) And the relative protein level of collagen II decreased significantly ().

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