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| Chemical | Exposure, species | Toxicities on NOX in the developing brain | Other findings in pups | References |
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| Sevoflurane | Mouse pups at PND6 were anesthetized with 3% sevoflurane in 40% oxygen for 6 h | p22phox protein expression was increased in the brain shortly after exposure | ROS, cytochrome c, and cleaved caspase-3 were increased in the brain shortly after exposure. Abnormal freezing behavior was observed at 11-13 weeks of age. These toxicities were suppressed by cotreatment with the NOX inhibitor | [78] |
| Sevoflurane | Mouse pups were anesthetized with 3% sevoflurane in 40% oxygen for 2 h daily from PND6 to PND8 | NOX2 protein expression was increased in FC and HC shortly after exposure | Apoptosis was increased in the brain shortly after exposure. Abnormal freezing behavior and the impairments of spatial learning and memory were observed at 9-11 weeks of age | [77] |
| Ethanol | Pregnant mice at GD8 were injected IP with ethanol (12 g/kg) | The mRNA expressions of Duox2, Noxa1, and Noxo1 were increased in the brains on GD18 | The mRNA expressions of Noxa1 and p67phox were increased in the placenta and liver, respectively, on GD18 | [81] |
| Ethanol | Pregnant mice at GD9 were injected IP with ethanol (2.9 g/kg) | The mRNA expressions of Duox1, Noxa1, Noxo1, p22phox, p67phox, and Rac1 were increased in the brains shortly after exposure | NOX activity, ROS generation, oxidative DNA damage, and apoptosis were increased in the brains shortly after exposure. These toxicities were suppressed by cotreatment with the NOX inhibitor | [82] |
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