Pyroptosis: A New Frontier in Kidney Diseases

Table 2

Potential medicines for the treatment of pyroptosis and kidney diseases.

Type of drugs	Small molecules or drugs	Molecular weight	Molecular formula	Variety of disease	References
NLRP3 inhibitor	Mdivi-1	353.2	C15H10Cl2N2O2S	AKI
	Quercetin	302.23	C15H10O7	DKD	[95]
	Curcumin	368.4	C21H20O6	DKD	[96]
	Allopurinol	136.11	C5H4N4O	DKD	[95]
	CP-456,773	404.5	C20H24N2O5S	Renal fibrosis	[97]
	Artemisinin	282.33	C15H22O5	Renal fibrosis	[98]
	EGCG	458.4	C22H18O11	LN	[99]
	Bay11-7082	207.25	C10H9NO2S	LN	[100]
	Piperine	285.34	C17H19NO3	LN	[83]
	Icariin	676.7	C33H40O15	IgAN	[101]
Caspase-1 inhibitor	β-Hydroxybutyrate	251.28	C13H17NO4	AKI	[104]
	Mizoribine	259.22	C9H13N3O6	Renal fibrosis	[105]
GSDMD inhibitor	Sodium butyrate	110.09	C4H7NaO2	DKD	[69]
	Catalpol	362.33	C15H22O10	DKD	[106]
	Geniposide	388.4	C17H24O10	DKD	[107]