Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers

Figure 1

Development of NMSCs due to the dysregulation of Wnt, HH, p53, and COX-2 signaling pathways in keratinocytes triggered by UVB radiation. UVB radiation can cause alterations in PTCH1, SMO, and SUFO in the HH pathway and p53 and β-catenin in Wnt pathway that will eventually drive constitutive expression of downstream effectors which are GLI1, β-catenin, and COX-2 favoring the overexpression of target genes (protooncogenes) like N-MYC leading to uncontrolled cell growth, survival, angiogenesis, and migration and invasion required for NMSCs (BCC, SCCs). “Created with http://BioRender.com/.”