Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers

Figure 2

The key targets of UVR in the PI3K/AKT/mTOR-S6K1 pathway. UVB exposure can cause various alterations in the PI3K/AKT/mTOR-S6K1 pathway where any functional loss of PTEN or RPTP-κ or hyperactivity of EGFR, Src, or AKT would eventually lead to constitutive cell survival, protein synthesis, cell cycle progression, and proliferation, which are the hallmarks of skin carcinogenesis. “Created with http://BioRender.com/.”