Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers

Figure 3

PI3K/AKT1, CSNK2A1 (CK2 α 1), MAPK, and NFE2L2 (NRF2) signaling pathways regulating NER’s pathway. The PI3K/AKT1 and MAPK pathways regulate XPC positively via EP300, the CSNK2A1 pathway also can affect positively both XPC and XRCC1-Lig3 complex, and the NRF2 pathway can enhance NER’s activity positively by inducing the expression of antioxidant enzymes inhibiting ROS. On the other hand, AKT also can inhibit XPC under certain conditions. “Created with http://BioRender.com/.”