Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and <i>In Vitro</i> Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Conformers</td><td class="align_center">Binding energy (kcal/mol)</td><td class="align_center">Inhibition constant (Ki) (<i>μ</i>M)</td><td class="align_center">Interacting residues</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">1</td><td class="align_center">-8.40</td><td class="align_center">697.83</td><td class="align_center">ARG199, ASN370, TRP372, GLU377</td></tr><tr><td class="align_left">2</td><td class="align_center">-7.84</td><td class="align_center">2.17</td><td class="align_center">ARG199, TRP372, GLU377</td></tr><tr><td class="align_left">3</td><td class="align_center">-7.73</td><td class="align_center">6.84</td><td class="align_center">ARG199, TRP372, PRO 350, GLU377</td></tr><tr><td class="align_left">4</td><td class="align_center">-7.24</td><td class="align_center">4.96</td><td class="align_center">ARG199, VAL352, TRP372, GLU377</td></tr><tr><td class="align_left">5</td><td class="align_center">-6.23</td><td class="align_center">26.91</td><td class="align_center">ARG199, PHE369, TRP372, GLU377, TYR489</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Top 5 conformers of predicted binding energy values of the protein-ligand complex during docking.</div>

Oxidative Medicine and Cellular Longevity

tab2

Table 2

Table 2: Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and <i>In Vitro</i> Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer 

Table 2 | Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer 