Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review

Table 1

Association between plasma levels of myeloperoxidase, serum amyloid A, lipoprotein phospholipase A2, glutathione peroxidase-3 and the presence or the risk of Alzheimer’s disease (AD), as reported in selected epidemiological studies.

Study	Study design		AD vs. controls
(i) Myeloperoxidase
Tzikas et al. [39]	Cross-sectional	55	↑
Cheng et al. [40]	Cross-sectional	199	↑
Marksteiner et al. [41]	Cross-sectional	56	↔
Wu et al. [42]	Cross-sectional	170	↔
(ii) Serum amyloid A
Cao and Chen [44]	Cross-sectional	352	↑
Shang et al. [45]	Cross-sectional	673	↑
Kindy et al. (CSF) [16]	Cross-sectional	31	↑
(iii) Lipoprotein phospholipase A2
van Oijen et al. [46]	Longitudinal	6713	↑
Fitzpatrick et al. [47]	Longitudinal	3320	↑
Bacchetti et al. [48]	Cross-sectional	83	↑
Doody et al. [49]	Cross-sectional	395	↑
van Himbergen et al. [50]	Longitudinal	541	↔
(iv) Glutathione peroxidase-3
Ceballos-Picot et al. [51]	Cross-sectional	74	↔
Serra et al. [52]	Cross-sectional	192	↔
Puertas et al. [15]	Cross-sectional	92	↓
Casado et al. [53]	Cross-sectional	150	↓
Rinaldi et al. [54]	Cross-sectional	141	↓
Vural et al. [55]	Cross-sectional	100	↓