Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas

Figure 6

Brusatol (BT) increased the cytotoxicity of cabergoline in GH3 and MMQ cells. (a) GH3 and MMQ cells were treated with BT (250 nM) and/or cabergoline (50 μM) for 24 h. Cell viability was measured by MTS assays, and (c) Western blot analysis was conducted to determine the level of p-4EBP1 and p-S6K1. (b) Representative images of colony formation assays. GH3 and MMQ cells were treated with BT (250 nM) and/or cabergoline (50 μM) for 24 h. Colony formation was allowed to proceed for 14 days. Data are presented as the . ; ; .

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