Deferasirox, an Iron-Chelating Agent, Improves Testicular Morphometric and Sperm Functional Parameters in a Rat Model of Varicocele

<div>DFX treatment activates the PERK/Nrf2/ARE ER/UPR pathway, but not the PERK/CHOP pathway in the testis of varicocelized rat. (a) Relative accumulation of the Nrf2 transcript. (b) Relative accumulation of the GPX4 protein. (c) Relative accumulation of the CHOP protein. (d) Representative western blots showing the detection of GPX4 and CHOP proteins. The relative accumulation of mRNA and proteins was normalized to the GAPDH transcript and <i>β</i>-actin antibody, respectively. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Deferasirox, an Iron-Chelating Agent, Improves Testicular Morphometric and Sperm Functional Parameters in a Rat Model of Varicocele 