H9c2 Cardiomyocytes under Hypoxic Stress: Biological Effects Mediated by Sentinel Downstream Targets

Figure 6

Biological effects of oxidative stress in high glucose-treated H9c2cells. The scheme shows an increase of cytotoxicity and oxidative stress and related effectors Rho-A/Rac1 and the downregulation of Bcl after exposure to high glucose. In addition, the preventive administration of the 1400 W iNOS inhibitor induces cell proliferation.