Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway

<div>Intranasal administration of rh-CXCL-12 improved short-term neurological outcome and attenuated brain edema at 24 h after SAH. (a) SAH grading score of each group. (b) Quantification of brain water content in the left hemisphere, right hemisphere, cerebellum, and brain stem at 24 h after SAH. (c, d) Intranasal administration of rh-CXCL-12 improved neurological performance on the modified Garcia and beam balance test at 24 h after SAH. (e) Representative pictures of the brain in the sham and SAH groups (subarachnoid blood clots were mainly presented around the circle of Willis). Vehicle: sterile distilled water. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway 