Oxidative Medicine and Cellular Longevity

Research Article

Integrative Network Analysis Revealed Genetic Impact of Pyruvate Kinase L/R on Hepatocyte Proliferation and Graft Survival after Liver Transplantation

Table 1

Clinical features of liver transplant cases.
CovariatesCharacteristics
Recipients (R)
 R-age (years)
 R-gender (M/F)67/12
 R-BMI (kg/m2)
 R-HBV infector (Y/N)62/17
 R-blood type (A/B/O/AB)33/8/33/5
 R-MELD score33 (27-40)
 R-Child-Pugh score11 (10-12)
 Indication for LT
 (Viral hepatitis-related cirrhosis/cholestatic cirrhosis/liver failure/liver cancer/others)24/5/12/13
Donors (D)
 D-age (years)
 D-gender (M/F)67/12
 D-BMI (kg/m2)
 D-HBV infector (Y/N)11/68
 D-blood type (A/B/O/AB)27/10/31/11
 D-ALT (U/L)40.0 (25.0-66.0)
 D-TB (μmol/L)17.2 (11.0-23.1)
 D-CR (μmol/L)87.0 (56.3-151.6)
 D-BUN (mmol/L)8.4 (5.2-11.0)
 D-sodium (mmol/L)146 (138-152)
 D-potassium (mmol/L)3.8 (3.7-4.3)
Grafts (G)
 PKLR-RQ1.0 (0.3-9.4)
 PKM-RQ1.0 (0.5-3.0)
 Steatosis (MaS/MiS/none)35/9/35
 Donation type (DCD/DBD)57/22
Surgery
 Surgical duration (min)303 (272-375)
 CIT (min)652 (567-744)
 WIT (min)7 (1-12)
 Blood loss (mL)1500 (800-2500)
 Blood product transfusion
  FFP (mL)780 (540-1120)
  RBC (U)5 (2-8)
  PCC (U)2000 (900-3000)
  ALB (g)125 (75-150)
  FIB (g)5 (0.5-10)
Posttransplant events
 Peak TB (μmol/L)211 (125-387)
 Peak ALT (U/L)2571 (1972-3255)
 Peak AST (U/L)6284 (4485-9712)
 EAD (Y/N)50/29
 PNF (Y/N)10/69
Follow-up duration (d)308 (35-980)
Data in normal distribution was presented by , and data in nonnormal distribution was presented by median (IQR (interquartile range)). Abbreviations: ALB: albumin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CIT: cold ischemia time; D: donor; DBD: donation after brain death; DCD: donation after cardiac death; EAD: early allograft dysfunction; F: female; FFP: fresh frozen plasma; FIB: fibrinogen; HBV: hepatitis B virus; LT: liver transplantation; M: male; MELD: model for end-stage liver disease; PCC: prothrombin complex; PNF: primary liver graft nonfunction; R: recipient; RBC: red blood cell; RQ: relative quantity; TB: total bilirubin; WIT: warm ischemia time.