Research Article
κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a
Figure 2
κ-OR agonist inhibited oxidative stress injury and reduced cardiomyocyte apoptosis in HF rats. (a) The expression of ROS in rats detected by IF ( μm). (b) Contents of oxidative stress factors (MDA, SOD, and CAT) in plasma detected by ELISA. (c) The rat myocardial apoptosis rate detected by TUNEL staining ( μm). (d) The expression levels of apoptosis-related proteins, Bax and Bcl-2, determined by Western Blotting; .
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