Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1<i>α</i>/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats

<div>PCOS-like rat ovarian dysfunction was improved by treatment with curcumin combined with exercise possibly via the suppression of ER stress. PCOS rats received 8 weeks of curcumin gavage, treadmill exercise, and curcumin combined with treadmill exercise treatment. (a–g) The expression of <i>Ar</i>, <i>Cyp11α1</i>, and <i>Cyp19α1</i> in ovaries was assessed by western blot assay, qRT-PCR analysis, and immunofluorescence. Three independent experiments were performed with similar results. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1<i>α</i>/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats 

Figure 4 | Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats 