Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis

Figure 4

HFD activated the JAK2-STAT3 signaling pathway in the knee articular cartilage of rats. Western blot analysis was used to detect JAK2-STAT3 signaling and SOCS3 protein expression at W5 (a), W15 (b), and W27 (c), and the corresponding bar graph data of JAK2-STAT3 signaling (d, e) and SOCS3 (f) were presented as , . Independent sample -test and one-way ANOVA were used to conduct statistical significance. Significant expression differences are shown as and .

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