Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis

Figure 5

HFD upregulated CD14/TLR4 expression in the knee articular cartilage of rats. The mRNA expression of CD14 and TLR4 was measured by RT-PCR (a, b). Western blot analysis was used to detect CD14 and TLR4 protein expressions at W5 (c), W15 (d), and W27 (e), and the corresponding bar graph data of JAK2-STAT3 signaling (f, g) were presented as , . Independent sample -test and one-way ANOVA were used to conduct statistical significance. Significant expression differences are shown as and .

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