Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis

Figure 6

Leptin regulated CD14 and TLR4 as well as SOCS3 and MMP-13 expressions through the JAK2-STAT3 pathway in chondrocytes. The protein expression of JAK2-STAT3 signaling, SOCS3, CD14, TLR4, and MMP-13 were measured by western blot analysis (a, d). The bar graph summarized data of blots for JAK2-STAT3 signaling (b, c), CD14 (e), TLR4 (f), MMP-13 (g), and SOCS3 (h). Data were presented as , . Independent sample -test and one-way ANOVA were used to conduct statistical significance. Significant expression differences are shown as , , and .

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