Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health-Promoting Abilities

Table 1

Typical examples of Glycyrrhiza glabra L. and glycyrrhizin salt-related side effects in humans.

Gender	Age (in years)	Consumption	Symptoms/complications	Reference
Man	70	Licorice candies, 60–100 g/daily for 4–5 years	Hypertension, hypokalemia, rhabdomyolysis	[190]
Woman	90	Antacid with licorice	Hypertension, hypokalemia, myoclonus, metabolic alkalosis	[191]
Woman	55	High amount of licorice, daily, for 4 years	Hypertension, hypokalemia	[192]
Woman	44	Chewing licorice sticks, 3 days	Edema, bilateral nocturnal hand pain, paresthesias in fingers, bilateral carpal tunnel syndrome	[193]
Woman	46	Herbal tea with licorice, 1-2 cups/daily for 7 years	Hypertension, hypokalemia, reduced plasma aldosterone, and renin	[194]
Woman	39	Herbal medicine with licorice/daily for 8 weeks	Hypertension, hypokalemia, muscle weakness, acute renal failure	[195]
Woman	38	Licorice root tea, 3 times per day for 2 months	Polymorphic, ventricular tachycardia	[196]
Man	52	Licorice, 1.5 g/daily for 2 months	Hypertension, severe asthenia, muscle cramps	[197]
Man	49	Herbal formulation containing licorice, for 1.5 years	Hypokalemia, somnolence, rhabdomyolysis, acute renal failure	[198]
Man	57	Licorice, 900 g/weekly for 3–4 months	Hypertension, acute visual impairment, hypokalemia	[199]
Man	72	Licorice, 2 oz/weekly for 1 month	Hypertension, metabolic alkalosis, severe hypokalemia, increase in rhabdomyolysis indexes myoglobinuria	[200]