VDAC1 Conversely Correlates with Cytc Expression and Predicts Poor Prognosis in Human Breast Cancer Patients

Table 6

Univariate and multivariate analyses of predictive factors for disease free survival in BC patients.

		Univariate		Multivariate
		value	Hazard ratio, 95% CI	value	Hazard ratio, 95% CI
VDAC1 expression		0.000	5.636 (2.454-12.942)	0.001	3.982 (1.723-9.207)
High	162
Low	57
Cytc expression		0.007	0.463 (0.265-0.811)	0.035	0.542 (0.307-0.959)
High	65
Low	154
Age		0.718	1.084 (0.699-1.683)
≤50	135
>50	84
TNM stage		0.000	3.879 (2.512-5.989)	0.028	1.772 (1.063-2.956)
I/II	153
III	66
Lymph node metastasis		0.000	4.717 (2.692-8.265)	0.003	2.690 (1.401-5.164)
No	95
Yes	124
Histological grade		0.000	5.399 (3.489-8.356)	0.000	2.998 (1.899-4.731)
G1/G2	165
G3	54
HER2 gene		0.075	1.568 (0.956-2.574)
Nonamplification	173
Amplification	46
ER status		0.033	0.613 (0.390-0.962)
Negative	122
Positive	97
PR status		0.001	0.442 (0.275-0.711)	0.016	0.553 (0.341-0.896)
Negative	124
Positive	95
Menopause
Before	125	0.184	1.339 (0.870-2.060)
After	94