Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Figure 5

Trigonelline can delay the progression of age-related diseases in C. elegans models of AD, PD, and HD Effect of trigonelline on the accumulation of A-synuclein in PD model nematodes; (C-D) Effect of trigonelline on the paralysis rate of AD model in nematode strains CL4176 and CL2006; (E) Effect of trigonelline on the accumulation of Poly-Q in PD model nematodes on day 2 and day 4, Statistical details and repeats of these experiments were summarized in Table S8.

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