Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Figure 6

Trigonelline prolongs lifespan through mitochondrial signaling pathways (A-G) Survival curves of isp-1 (qm150), clk-1(e2519)III., and mev-1(kn1)III. raised at 20°C on NGM plates containing either no trigonelline or 50 μM trigonelline in lifespan assays (p >0.05). Lifespan was analyzed using Kaplan-Meier analysis and p values were calculated using log-rank test. Statistic details and repeats of these experiments were summarized in Table S4.

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