Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

<div>Photomicrographs (H&amp;E; 400x) of kidney sections of DEN/AAF/CCl4-administered rats treated with STE, Sm, and Sb from the 1st week of carcinogens-induction till the end of the experiment showing no histological changes in group-administered STE (a, b) as well as groups supplemented with Sb (e, f) in addition to vacuolation of the renal tubular epithelium (short arrow), congestion of glomerular tuft (long arrow) (c), and focal mononuclear cell infiltration (long arrow) (d) in rats treated with Sm.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways

Figure 3 | Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways 