TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro

<div>Cysteine depletion blocks the GSH/GPX4 pathway in both K562/G01 and K562 cells. (a) The levels of GSH were tested in K562/G01 and K562 cells cultured in normal or cysteine depletion condition for 24 h. (b) The activity of GPX4 was tested in K562/G01 and K562 cells cultured in normal or cysteine depletion condition for 24 h. GSH represents for reduced glutathione; GPX4 represents for glutathione peroxidase 4; control represents for normal condition (0.0652 g/L cysteine). Treat represents for cysteine depletion condition (0 g/L cysteine). 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Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro 