TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro

Figure 6

Cysteine depletion induces K562 cell ferroptosis after inhibiting the activity of TXNRD1. (a) Cell viability of K562 cells treated with auranofin or auranofin and Fer-1 and cultured in cysteine depletion condition was measured using the MTS kit. (b) TEM images showed the cell ultrastructure changes of K562 cells treated with auranofin under cysteine depletion condition (). (c, d) ROS and MDA levels of K562 cells treated with auranofin under cysteine depletion condition were measured. Auranofin: 1 μM. vs. control group, vs. control group, vs. control group, ^# vs. auranofin group, ^## vs. auranofin group, and ^### vs. auranofin group.

(a)

(b)

(c)

(d)