Botanical Drug Puerarin Ameliorates Liposaccharide-Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

Figure 1

Puerarin ameliorated depressive-like behaviors in the LPS-challenged mice. (a) The chemical structure of puerarin was shown. (b) The design of the animal experiments. Mice were separated into 5 groups: control, LPS, and LPS+puerarin (30, 60, or 120 mg/kg). After drug treatment, mice were assessed for depressive-like behaviours, and brain tissue was collected for the bioassays. (c) Forced swim test (FST). The depressive-like behaviors of mice were evaluated by measuring immobility time during 4 min. (d) Tail suspension test (TST). The depressive-like behaviors of mice were evaluated by measuring immobility time during 6 min. The data were presented as (). ; ; .

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