Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress

<div>Rap1GAP is upregulated in hypertrophic cardiomyocytes. (a) mRNA level of Rap1GAP in vehicle- or Ang II-treated cardiomyocytes determined using qRT-PCR. (b) Western blot analysis for Rap1GAP in Ang II-treated cardiomyocytes at different time points. (c) Western blot analysis for Rap1GAP expression in phenylephrine-treated cardiomyocytes. (d) The expression level and localization of Rap1GAP detected by double-label immunofluorescence staining. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress 