Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress

<div>Rap1GAP overexpression aggravates Ang II-induced ROS production and apoptosis. (a) Phosphorylated protein and total protein expression of AMPK, AKT, mTOR, and p70s6K measured using Western blot analysis. (b) ROS production in Rap1GAP overexpressing and control cardiomyocytes evaluated using DHE fluorescent dyes. Scale bar: 50 <i>μ</i>m. (c) Cell apoptosis determined by TUNEL staining. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress 