Inhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus

<div>The Keap1/Nrf2 signaling pathway was significantly inhibited in the sensitive mice. (a, b) The protein levels of Keap1, Nrf2, HO-1, and NQO1 in the pancreatic islets of the mice were detected by Western blot analysis. (c) Pairwise correlation between blood glucose concentrations and protein levels of Keap1, Nrf2, HO-1, and NQO1. (d) Pairwise correlation between insulin levels and protein levels of Keap1, Nrf2, HO-1, and NQO1. The correlations were analyzed by using Pearson analysis. 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172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.289,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> compared with the tolerant group.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Inhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus 