Inhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus

Figure 8

Schematic diagram of mechanism on this research. The Keap1/Nrf2 signaling pathway is closely involved in the pathogenesis and progression of T1DM. The Keap1/Nrf2 signaling pathway could effectively suppress ALX-stimulated intracellular ROS overproduction to protect pancreatic β-cell from oxidative stress-induced DNA damage, thereby contributing to the suppression of T1DM development. Conversely, inhibition of the Keap1/Nrf2 signaling pathway significantly promotes the progression of T1DM.