Trophoblasts Modulate the Ca<sup>2+</sup> Oscillation and Contraction of Myometrial Smooth Muscle Cells by Small Extracellular Vesicle- (sEV-) Mediated Exporting of miR-25-3p during Premature Labor

<div>miR-25-3p alleviated LPS-induced oxidative stress and inflammation response in the placenta. The pregnant mice were injected with 20 <i>μ</i>g LPS at P16; then, the placenta tissues were collected at 7 h after LPS injection. The expression of 4-hydroxynonenal (4-HNE) in the placenta was detected by immunohistochemistry (a). The superoxide (SOD) activity and glutathione (GSH) and malondialdehyde (MDA) levels in the placenta were determined by using commercial kits (b). The TNF-<i>α</i> and IL-6 levels in the placenta were also detected (c).</div>

Oxidative Medicine and Cellular Longevity

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Figure 2: Trophoblasts Modulate the Ca<sup>2+</sup> Oscillation and Contraction of Myometrial Smooth Muscle Cells by Small Extracellular Vesicle- (sEV-) Mediated Exporting of miR-25-3p during Premature Labor 

Figure 2 | Trophoblasts Modulate the Ca2+ Oscillation and Contraction of Myometrial Smooth Muscle Cells by Small Extracellular Vesicle- (sEV-) Mediated Exporting of miR-25-3p during Premature Labor 