RXRα Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc

Figure 4

RXRα promoted p66shc expression after spinal cord injury. (a) Western blot analysis showed that RXRα overexpression promoted p66shc expression in primary spinal cord neurons cultured in vitro, while RXRα interference inhibited p66shc expression in primary spinal cord neurons cultured in vitro. (b) Real-time PCR and luciferase assays showed that RXRα inhibited the expression of p66shc at the mRNA level by binding to the promoter region of p66shc. /group; vs. control, .

(a)

(b)