TNF-α Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway

Figure 2

TNF-α is identified as an important inflammatory factor mediating intestinal ischemia-reperfusion- (IIR-) induced remote lung injury. Mouse plasma was isolated, and the plasma levels of inflammatory factors TNF-α, MPO, IL-1β, IL-6, IL-8, and IL-18 were measured using ELISA (a); the levels of TNF-α in the lung tissue (b), plasma (c), and alveolar lavage fluid (BALF) (d) were further compared using ELISA. Each bar represents the ( per group). , , one-way ANOVA with Tukey test. Sham: sham-operated group; IIR: intestinal ischemia-reperfusion model group.

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