TNF-α Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway

Figure 3

TNF-α inhibitors alleviate intestinal ischemia-reperfusion- (IIR-) induced lung injury. A mouse model of IIR injury was constructed and treated with a TNF-α inhibitor, followed by using hematoxylin and eosin (HE) staining to detect the pathomorphological changes in the lung tissue (a). The extent of lung injury was assessed using HE staining of lung tissue (b), and the water content of lung tissue was also determined (c). Each bar represents the ( per group). , , one-way ANOVA with Tukey test. Sham: sham-operated group; IIR: intestinal ischemia-reperfusion model group; lenalidomide: group treated with intravenous administration of lenalidomide (10 mg/kg) alone; IIR+lenalidomide group: immediate intravenous administration of lenalidomide (10 mg/kg) at the onset of IIR.

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