TNF-α Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway

Figure 7

TNF-α inhibitor and Bcl-2 inhibitor alleviated the inflammatory response of lung tissue during intestinal ischemia-reperfusion (IIR). A mouse model of IIR injury was constructed and treated with TNF-α inhibitor lenalidomide or Bcl-2 inhibitor ABT-199, followed by performing ELISA to detect the levels of inflammatory factors TNF-α (a), IL-6 (b), and IL-1β (c) in the lung tissue. Each bar represents the ( per group). , , one-way ANOVA with Tukey test. Sham: sham-operated group; IIR: intestinal ischemia-reperfusion model group; ABT-199: intravenous administration of ABT-199 (10 mg/kg) alone; ABT-199+IIR group: immediate administration of ABT-199 (10 mg/kg) at the onset of IIR; lenalidomide: intravenous administration of lenalidomide (10 mg/kg) alone; IIR+lenalidomide group: immediate intravenous administration of lenalidomide (10 mg/kg) at the onset of IIR.

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