Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

<div>General procedure for the synthesis of target compounds 5, 6, and 7a-l. Reagents and conditions: (i) thionyl chloride (SOCl<sub>2</sub>), dicloroethane, reflux, 2 h; (ii) 4-aminibenzoic acid, triethylamine (TEA), acetonitrile, stirring, rt; (iii) thionyl chloride (SOCl<sub>2</sub>), dichloroethane, reflux, 2 h; (iv) cyclohexylamine, treithylamine (TEA), acetonitrile, reflux, 2 h; (v) benzylamine, treithylamine (TEA), acetonitrile, reflux, 2 h; (vi) app. amine, treithylamine (TEA), acetonitrile, reflux, 2 h.</div>

Oxidative Medicine and Cellular Longevity

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Scheme 1

Scheme 1: Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation 

Scheme 1 | Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation 