Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

<div>General procedure for synthesis of target compounds 18a-c. Reagents and conditions: (i) chloroacetylchloride, DMF, stirring, 12 h; (ii) MeOH, sulfuric acid, reflux, 4 h; (iii) hydrazine hydrate, EtOH, reflux, 8 h; (iv) (1) carbon disulfide, KOH, EtOh, reflux, 12 h, (2) HCl; (v) KOH, absoluteEtOH, reflux, 0.5 h; (vi) Comp 17a-c, DMF, Kl, heating, 4 h.</div>

Oxidative Medicine and Cellular Longevity

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Scheme 3: Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation 

Scheme 3 | Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation 