Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression

Figure 2

Effects of 10 μM nobiletin pretreatment on the expression of circadian genes (a) and effects of 10 μM nobiletin pretreatment on LPS-disturbed expression of circadian (b). Clock, Bmal1, Per1, Per2, Per3, Cry1, Cry2, Rev-erbα, Rev-erbβ, Rorα, Dbp, and Npas2, in BV-2 cells. Relative mRNA levels were measured using qRT-PCR. Data is presented as the (). , , and , compared to the DMSO blank control. ^# of treatments compared to the LPS-induced circadian clock disorder.

(a)

(b)