MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease

Figure 3

Multiforms of MUTYH protein detected in the human brain. (a) Western blot detection of MUTYH proteins in non-AD and AD hippocampal extracts. (b) A quantitative analysis of the 2 major bands (60 and 47 kDa) and multiple bands of MUTYH protein with molecular weights lower than 47 kDa in non-AD and AD hippocampal extracts. The data were normalized by the β-actin levels. . Statistical analyses were performed with Wilcoxon’s rank sum test, and the value is shown in each graph. The levels of multiple bands of MUTYH protein with molecular weights lower than 47 kDa were significantly increased in the AD hippocampal extracts.

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