MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease

Figure 8

MUTYH deficiency suppressed the morphological alteration of microglia in the App^{NL-G-F/NL-G-F} brain. (a) Immunofluorescent micrograph of hippocampal microglia stained for Iba-1 (green) in six-month-old female wild-type (Wt), App^{NL-G-F/NL-G-F} (NL-G-F), and App^{NL-G-F/NL-G-F}·Mutyh^-/- (NL-G-F·Mutyh) mice. Nuclei were counterstained with DAPI (blue). . (b) Three-dimensional reconstruction of microglia surrounding Aβ plaque in the six-month-old female hippocampus. . (c) Morphological parameters of hippocampal microglia (cell surface area, total cell volume, and sphericity). Each parameter was normalized by the wild-type value. The number of microglia examined was 101 to 107 in each group. The data are expressed as the (). Statistical analyses were performed with a one-way ANOVA ( value shown in each bar graph) followed by the post hoc Tukey-Kramer HSD test. and .

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