MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease
Table 2
The altered expression of marker genes for various brain cell types in the hippocampi of 6-month-old female wild-type, AppNL-G-F/NL-G-F, and AppNL-G-F/NL-G-F·Mutyh-/- mice.
Cell type
Marker gene
Relative expression (% wild type)
AppNL-G-F/NL-G-F
AppNL-G-F/NL-G-F·Mutyh-/-
NSCs/NPCs
Ascl1
87.06
77.38
Bmp4
87.66
99.31
Dcx
95.93
97.27
Egf
106.44
106.44
Igf2
144.39
125.7
Notch2
104.97
101.4
Shh
93.3
90.75
Sox2
100
90.75
Mean
102.47
98.63
SD
17.21
13.13
Neurons
Chga
104.25
92.02
Eno2
103.53
102.81
Nefh
100
106.44
Nefl
103.53
108.67
Nefm
104.25
107.18
Rbfox3
93.3
109.43
Snap25
98.62
100
Syp
96.59
95.93
Syt1
91.38
92.02
Tubb2a
97.94
93.95
Mean
101.64
100.87
SD
4.4
6.62
Astrocytes
Gfap
141.42
155.83
S100b
102.81
98.62
Glul
97.27
98.62
Slc1a2
92.02
100
Slc1a3
99.31
101.4
Aqp4
99.31
99.31
Mean
105.36
108.96
SD
16.45
20.98
Oligodendrocytes
Mbp
96.59
90.13
Sox10
91.38
86.45
Mog
93.3
80.11
Cnp
94.61
92.02
Apc
101.4
101.4
Gstp1
102.81
90.75
Plp1
96.59
95.93
Mag
97.94
87.06
Mean
96.83
90.48
SD
3.62
5.99
Microglia
Aif1
110.96
113.29
Cd68
197.25
171.71
Lgals3
106.44
91.38
Adgre1
122.26
123.11
Mean
134.23
124.87
SD
36.84
29.38
Genes whose expression differed significantly between AppNL-G-F/NL-G-F and AppNL-G-F/NL-G-F·Mutyh-/- are shown in bold, and genes that differed significantly from wild-type samples are italics or bold-italics. NSC = neural stem cell; NPC = neural progenitor cell; SD = standard deviation.
