Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease

Table 3

Cox proportional hazard analysis (enter regression) showing predictors for all-cause mortality in univariate and multivariate models, in patients with rs11780592 EPHX2 and rs2741335 EPHX2 polymorphism.

		HR	CI
All-cause mortality
Model 1^a
	rs11780592 EPHX2	2.74	1.40-5.35	0.003
	rs2741335 EPHX2	0.85	0.58-1.26	0.42
Model 2^b
	rs11780592 EPHX2	2.61	1.32-5.17	0.006
CV events (fatal and nonfatal)
Model 1^a
	rs11780592 EPHX2	1.10	0.72-1.69	0.67
	rs2741335 EPHX2	0.77	0.54-1.11	0.16

Model 1^a = univariate model. Model 2^b = multivariate model, adjusted for age, sex, and previous history of cardiovascular disease. HR = hazard ratio; CI 95% = confidence interval.