Nrf2-ARE Signaling Partially Attenuates Lipopolysaccharide-Induced Mammary Lesions via Regulation of Oxidative and Organelle Stresses but Not Inflammatory Response in Mice

Figure 5

Effects of LPS and Nrf2 phenotype (+/+, +/-, and -/-) on oxidative stress and antioxidation in the mammary gland. (a) mRNA expression changes in genes of antioxidation in the LPS treatment groups between WT and Nrf2 (-/-) mice. Data represents the log₂(foldchange) (). Data marked with represent , and marked with represent . (b–k): (b) T-AOC, the protein abundance of (g) GSH, (h) GSH/GSSG ratio, mRNA abundance of (c) NQO1, (d) CAT, (e) Nrf2, (f) HO-1, (i) GCLC, (j) GCLM, and (k) xCT in mice. test was used to determine the differences between LPS and PBS treatments. ANOVA followed by Tukey’s multiple comparison was used to determine the differences among three genotypes of mice. Data represent (). The data marked with represent a significant difference (), and marked with or ^## represent a highly significant difference ().

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