Apelin/APJ-Manipulated CaMKK/AMPK/GSK3β Signaling Works as an Endogenous Counterinjury Mechanism in Promoting the Vitality of Random-Pattern Skin Flaps

Figure 8

Apelin13 enhanced the migration and tube formation of HUVECs under short-time OGD via CaMKK/AMPK/GSK3β signaling. (a, d, g, j) Transwell migration assay and tube formation images of HUVECs with different treatments. (b, e, h, k) Statistical histograms of cell migration. (c, f, i, l) Histogram of tube formations in all different groups. independent experiments. “” means compared with the normal control group; “#” means compared with the OGD group; “@” means compared with the OGD+apelin13 group; “&” means compared with the OGD+apelin13+STO-609 or DM and BX795 groups. , .

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