Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat

Figure 6

Rhodamine B-labelled peptide TP-WW-623 colocalises with lysosomes. (a) Lysosomes in SH-SY5Y cells were labelled with LAMP1-GFP before incubation with 50 μM rhodamine B-labelled peptide TP-WW-623 at 37°C. Cell images were recorded on three consecutive days to observe the colocalisation of peptides and lysosomes (see also Figure S2). (b) Images of cells recorded by SIM at day 3 to illustrate the colocalisation of peptides and lysosomes. White dashed lines indicate the cell boundary. Enlarged views of the white boxed regions are shown in the bottom panel (see also Figure S2 and Video 1).