Polygonatum sibiricum Polysaccharides Protect against MPP-Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways

Figure 5

Oral administration of PSP presents no toxicity for mice. (a) The monitoring curve of body weight demonstrated no significant difference between the vehicle (sterile water) and PSP treatment group. (b) Representative images of H&E staining of the brain, liver, and kidney. C57BJ/6 mice regardless of gender (20-25 g) were treated with a daily dose of 45 mg/kg of PSP for 12 consecutive weeks (). Continuous weekly weight records were kept, and the brain, liver, and kidney were collected for pathological analysis at the end of the study. Scale bar, 40 μm.

(a)

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