T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway

Figure 5

T0901317 attenuated neurological deficits and the number of apoptosis neurons, which were abolished by GSK2033 and IRF-1 CRISPR activation. (a) Modified Garcia and (b) beam balance scores, per group. Error bars were represented as median with interquartile range using Kruskal-Wallis test followed by the Dunn post hoc test. (c) The quantification of TUNEL staining. Error bars were represented with using one-way ANOVA followed by the Tukey post hoc test, per group. (d) TUNEL staining of all 6 groups.  μm. vs. Sham group; ^# vs. SAH+vehicle group; ^& vs. SAH+DMSO+T0901317 group; ^@ vs. SAH+Scr CRISPR+T0901317 group. Scr CRISPR: scramble CRISPR. Vehicle, 30% dimethyl sulfide (DMSO).

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