T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway

Figure 6

GSK2033 abolished the antiapoptotic effect of T0901317 at 24 h after subarachnoid hemorrhage (SAH). (a) Representative Western blot bands. (b–i) Quantification of LXR-α, LXR-β, IRF-1, PUMA, Drp1, Bcl-2, Bax, and cleaved caspase-3 in the ipsilateral hemisphere at 24 h after SAH. Data was represented as . vs. Sham group, ^@ vs. SAH+vehicle group, and ^# vs. SAH+DMSO+T0901317 group; One-way ANOVA and Tukey’s post hoc test, per group. Vehicle, 30% dimethyl sulfide (DMSO).

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